However, a comparative study using samples obtained from patients with non-small cell lung cancer showed greater sensitivity of the PD-L1 immunohistochemistry assay used in this study (Dako 73–10) compared with that used in the KEYNOTE 002 and 006 studies (Dako 22C3) [32], suggesting a possible discrepancy in the ability to identify truly PD-L1–negative tumors. This evidence concerns the gene CD274 and non-small cell lung carcinoma.