CD274 and ocular melanoma: If confined to patients with non-ocular melanoma, objective responses were observed in 8 of 14 patients (57.1% [95% CI, 28.9–82.3]) with PD-L1–positive tumors vs an ORR of 0% (95% CI, 0–26.5) in patients with PD-L1–negative tumors (n = 12) (Fisher exact test, P = 0.002); of 9 patients whose tumors were not evaluable for PD-L1 expression, 3 objective responses were observed (33.3% [95% CI, 7.5–70.1]) (Additional file 3: Table S2).