If confined to patients with non-ocular melanoma, median PFS was 7.9 months (95% CI, 1.3-not estimable) in patients with PD-L1–positive tumors, 1.3 months (95% CI, 1.1–6.3) in patients with PD-L1–negative tumors, and 3.7 months (95% CI, 1.4-not estimable) in patients whose tumors were not evaluable for PD-L1 expression. This evidence concerns the gene CD274 and ocular melanoma.