One study showed that WISP2 is overexpressed in the gastrointestinal peptide (GIP)-dependent corticotropin/ACTH-independent macronodular adrenal hyperplasia (AIMAH), suggesting that WISP2 could play a role in adrenocortical hyperplasias and tumors [101]. The gene discussed is CCN5; the disease is Cushing syndrome due to macronodular adrenal hyperplasia.