Since MYC is a central oncogene inducing leukemic transformation in T cell acute lymphoid leukemia (T-ALL) and acute myeloid leukemia (AML) [11, 12], influencing AKT, ERK1/2 and MYC signaling may enhance the efficacy of chemotherapy in ALL and AML [13–20]. Here, MYC is linked to acute myeloid leukemia.