Intracellular Ca2+ overload may activate a variety of intracellular signal transduction pathways [43], including Ca2+-dependent PKC/p38 MAPK/NF-κB cascades to induce MG activation, control a range of cellular process, including chemotaxis, phagocytosis, and secretion of cytokines. This evidence concerns the gene NFKB1 and myasthenia gravis.