Moreover, the correlation between increased RAB5A expression [75,82,84,85,86,87,88,89] and decreased PIK3R1 expression in cancer [106,107] warrants further investigation, as a possible feature of oncogenic adaptation where metastasis via Rab5-mediated cell migration progresses unchecked due to loss of regulation by p85α. The gene discussed is RAB5A; the disease is cancer.