In light of the connection established between IL6-mediated stimulation of ribosome biogenesis in chronic inflammatory diseases and cancer, it will be worthy to define the role of increased ribosome biogenesis also in those metabolism-related diseases characterized by a persisting pro-inflammatory status with increased cancer onset, such as the insulin resistant states of obesity and type 2 diabetes. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.