Moreover, our study suggests that KRT19 directly interacts only with β-catenin and is translocated to LEF1/TCF7 promoter to promote colon cancer progression, whereas KRT19 directly interacts with the β-catenin/RAC1 complex and is predominantly translocated to the NUMB promoter in breast cancer and is suppressed through attenuation of Notch signaling (see Figure 6a,b). This evidence concerns the gene NUMB and malignant colon neoplasm.