RAC1 can facilitate β-catenin nuclear translocation signaling, which induces NUMB transcription and Notch signaling crosstalk; however, we did not find that RAC1 is associated with β-catenin in colon cancer, perhaps providing supporting evidence for the NUMB-independent phenomenon in colon cancer (see Figure 5c,d). The gene discussed is NUMB; the disease is colonic neoplasm.