HES1 and malignant colon neoplasm: Interestingly, we revealed that although expression of several Notch signaling pathway-related genes such as NOTCH1, MAML1, RBPjK, HES1, H-RAS, and CCND1 was significantly increased upon KRT19 knockdown in breast cancer, colon cancer cells showed the opposite effect in the expression of Notch signaling pathway-related genes upon KRT19 knockdown (Figure 4d).