Given the severe DCM phenotype in the proband at age 10 months and the presence of two different mutated genes in two different cardiomyocyte components, we believe that the LAMA4 p.Asp1309Asn variation found here may cause a mild defect in LAMA4 function that only manifests in combination with the digenic inheritance of the MYH7 p.Asp1309Asn mutation. This evidence concerns the gene LAMA4 and familial dilated cardiomyopathy.