Complex 1a exhibited the best inhibition efficiency among the four scaffolds towards either the TNF-α-induced NF-κB pathway (TNF = tumor necrosis factor; NF-κB = nuclear factor kappa light chain enhancer of activated B cells) or IL-6-induced STAT3 pathway (IL-6 = Interleukin 6; STAT3 = Signal transducer and activator of transcription 3) in DU145 prostate cancer cells. This evidence concerns the gene NFKB1 and Familial prostate cancer.