Although mTOR expression was increased in patients with multinodular disease, aligning with previous reports [8,10], it was not associated with other established histological features indicating worse prognosis such as microvascular invasion or tumour differentiation, probably because of a confounding effect of pre-LT locoregional ablative therapies, which are more frequently used nowadays than in previous series [8,10]. This evidence concerns the gene MTOR and neoplasm.