AKT1 and neoplasm: There was a not significant trend for intra-tumour reduced expression of p-Akt (p = 0.37), p-AMPK (p = 0.2), p-p70S6K (p = 0.6) and p-S6RP (p = 0.07) in patients with prior locoregional ablation (Figure 1 and Figure 2).