AOC3 and obesity due to melanocortin 4 receptor deficiency: However, since SSAO/VAP-1 is another amine oxidase highly expressed in adipocytes, and since its substrates can mimic several insulin effects, such as stimulation of glucose transport [34], we also associated the SSAO inhibitor semicarbazide to the treatment performed with pargyline and observed a potentiation of their anti-obesity effects (Figure 1).