It is now accepted that prion diseases have a neuroinflammatory component that may play a critical role in neurodegeneration [35], with increases in numerous proinflammatory cytokines and chemokines such as IL-1α and β, IL-12p40, TNF, CCL2–CCL6, and CXCL10 in the brains of mice with clinical disease. Here, CCL2 is linked to prion disease.