pSTAT3 and NF-κB have been shown to affect transcription at the promoters controlling many of the genes that are increased in the CNS during prion disease (i.e., Cxcl10, Ccl4, and A2m) [49,50,51,52,53], and together they strongly influence the expression of acute phase proteins such as haptoglobin, ceruloplasmin, α1-antichymotrypsin, and serum amyloid A [52,54], which are increased in the serum and brain during scrapie infection [5,55,56,57]. Here, NFKB1 is linked to prion disease.