Indeed, tumor cells can activate the coagulation cascade either through the production of pro-coagulant molecules, such as tissue factor (TF) [34,35] and “cancer pro-coagulant” (CP) [36], or by inducing a pro-coagulant phenotype in blood cells with which they interact, such as monocytes, platelets, and endothelial cells (Figure 1) through the expression of various adhesion molecules, including two selectin ligands to platelets (P-selectin) or endothelial cells (E-selectin) [37], both concurring to facilitate tumor cell invasion and metastasis [38,39,40]. The gene discussed is TF; the disease is neoplasm.