Notably, a recent clinical trial of large hemispheric infarction that studied pharmacological blockade of SUR1-TRPM4 using intravenous glibenclamide reported that brain swelling, measured as midline shift, was reduced by half with drug [121], giving further evidence of a major role for SUR1-TRPM4 in brain swelling. The gene discussed is TRPM4; the disease is infarction.