Notably, a recent clinical trial of large hemispheric infarction that studied pharmacological blockade of SUR1-TRPM4 using intravenous glibenclamide reported that brain swelling, measured as midline shift, was reduced by half with drug [121], giving further evidence of a major role for SUR1-TRPM4 in brain swelling. This evidence concerns the gene ABCC8 and infarction.