IL6 and major depressive disorder: A larger study published by Révész and coworkers in 2016, including 2750 participants of the Netherlands Study of Depression and Anxiety, showed that the relationship between psychopathology and LTL was modulated by levels of inflammatory markers (CRP and IL-6) as well as by waist circumference, triglycerides, high-density lipoprotein cholesterol, and cigarette smoking [66].