We also observed a marked increase in IL-13 levels in the skin homogenates of AD animals of both genotypes compared to their respective control groups (AD WT: 1.17 ± 0.09 ng/mL, AD AnxA1-/-: 1.24 ± 0.23 ng/mL, p < 0.001 vs. Naïve and Sham of both genotypes). Here, ANXA1 is linked to Alzheimer disease.