Changes in nuclear envelope function in other neurodegenerative diseases, including ALS-FTD due to repeat expansions in C9orf72, Huntington’s disease, and AD, have recently been reported (Freibaum et al., 2015, Grima et al., 2017, Jovičić et al., 2015, Zhang et al., 2015). Here, C9orf72 is linked to Alzheimer disease.