Consistent with this, we found that the nuclear lamina was grossly disrupted in neurons that had high levels of hyperphosphorylated (AT8+) tau and neurofibrillary tangles in the post-mortem FTD-MAPT IVS10+16 cerebral cortex (Figures 5C and S4B), and those neurons frequently contained pronounced nuclear lamina invaginations (Figures 5C and S4B). This evidence concerns the gene MAPT and frontotemporal dementia.