The microtubule-associated protein tau (MAPT; tau) is involved in the pathogenesis of several different forms of dementia, including Alzheimer’s disease (AD), progressive supranuclear palsy, Pick’s disease, corticobasal degeneration, and frontotemporal dementia (FTD) (Lee et al., 2001, Spillantini and Goedert, 2013). This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.