Most proteins that were higher expressed in APL were involved in the pro‐apoptotic pathway (e.g., BCL2, BCL2L1, DIABLO, YAP1p, YWHAZ) or were linked to a higher proliferation (e.g., CDKN2A, PIK3CA), which may suggest a more pro‐apoptotic tendency of those cells, and that once the differentiation block is abrogated by the ATRA treatment, those cells tend to be more sensitive to the ATO‐induced apoptosis. Here, PIK3CA is linked to acute promyelocytic leukemia.