SLU7 and leukemia: selected a multidrug‐resistant leukemia cell line (HL‐60[R]) and a non‐resistant cell line, which they exposed to ATRA, followed by a sequential increase of the concentration.29 They found differential expression of genes involved in oxidative phosphorylation and metabolism in HL‐60[R] cells, as well as upregulation of genes involved in protein synthesis, such as eukaryotic translation initiation factors, transcription and elongation factors, and splicing factors.