Further, in addition to T1D (Table 2), 5 long-term patients have developed also AT (autoimmune polyglandular syndrome Type 3 variant, APS3v); of these 3 were affected by Hashimoto’s thyroiditis (HT), confirmed by the presence of circulating Tg and TPO AAbs and echography pattern of diffuse hypoechogenicity, one patient had developed HT and vitiligo and one Basedow’s disease. This evidence concerns the gene TPO and type 1 diabetes mellitus.