The expression and activity of CaMKII are enhanced in patients having heart failure.103, 104 Furthermore, the transgenic overexpression of CaMKII induced cardiac hypertrophy and dilated cardiomyopathy.105, 106 Structural heart disease may be prevented by CaMKII inhibitors.107, 108 Moreover, cardiac remodelling was attenuated in mice with global deletion of CaMKIIδ.109, 110 Backs et al. This evidence concerns the gene CAMK2G and heart disorder.