PRKG1 and cardiac hypertrophy: Human miR‐181 has been found in bone marrow, retina and vascular development.51, 53 Furthermore, the expression of miR‐181b was up‐regulated in the blood of patients with myocardial hypertrophy, suggesting that miR‐181b might play a role in both disease pathology and progression.54 Myocardial hypertrophy triggered by stimulation of primary myocardial cells with PE presented a negative correlation between miR‐181b and PKG 1.54 The results suggest that miR‐181b is a promising molecular marker for the clinical diagnosis and treatment of cardiac hypertrophy.