Fucoxanthin depresses tumour‐induced lymphangiogenesis by down‐regulating secretion and mRNA level of VEGF‐C on MDA‐MB‐231cells and expression of VEGF‐C and VEGFR‐3 on HLEC, including NF‐κB degradation after inhibition of Akt and PI3K phosphorylation. This evidence concerns the gene FLT4 and neoplasm.