Importantly, recent reports suggest that FTO regulate mitochondria content through mediating mitochondrial fusion, fission and biogenesis‐associated genes expression as a N6‐methyladenosine RNA demethylase.35, 36 To the point, we aim to explore the biological function of FTO in the post‐transcriptional modification of mitochondrial biogenesis and its subsequent influence in ccRCC and also explore the underlying molecular mechanism through identifying its key mRNA targets. Here, FTO is linked to nonpapillary renal cell carcinoma.