Moreover, analyses of previously published gene expression datasets and TCGA database showed that FTO was significantly down‐regulated in various types of human cancer, such as breast, endometrial, uterine cervix cancer and bladder cancer (P value = 0.05) (Fig. S1A), and FTO low expression correlated with poor prognosis in human cancers, including endometrial cancer, lung cancer, rectum adenocarcinoma and pancreatic cancer (Fig. S1B), which further suggested that FTO may play an antioncogenic role in progression and development of various cancer types. This evidence concerns the gene FTO and rectum adenocarcinoma.