Consequently, VHL loss of function in ccRCC leads to constitutive activation of HIF‐α, which promotes tumorigenesis through transcriptional activation of genes mediating angiogenesis,10 anti‐apoptosis11 and metabolism.12 Constitutive activation of HIF transcription factors have been placed a high value on metabolic reprogramming in ccRCC. The gene discussed is VHL; the disease is nonpapillary renal cell carcinoma.