But PGC‐1α, as a central regulator of mitochondrial function, cannot be compensated for by the other family members.15, 16 Accumulating evidence indicates PGC‐1α play a dualistic role in cancer, with reports of tumour suppression and pro‐tumorigenic effects of PGC‐1α expression in variant cancer types.17, 18, 19 A convincingly better understanding of the role of PGC‐1α in variant tumour types will be highly significant in exploring whether this target will be amenable as anticancer agents in ccRCCs. Here, PPARGC1A is linked to neoplasm.