PPARGC1A and cancer: But PGC‐1α, as a central regulator of mitochondrial function, cannot be compensated for by the other family members.15, 16 Accumulating evidence indicates PGC‐1α play a dualistic role in cancer, with reports of tumour suppression and pro‐tumorigenic effects of PGC‐1α expression in variant cancer types.17, 18, 19 A convincingly better understanding of the role of PGC‐1α in variant tumour types will be highly significant in exploring whether this target will be amenable as anticancer agents in ccRCCs.