IRS1 and diabetes mellitus: 2011). We found that groups treated only with DEXA had reductions in the IRS‐1/2 gene, whereas N‐3 supplementation alone reduced the expression of IRS‐1. In specific conditions, such as diabetes, N‐3 can increase IRS‐1 gene expression (Hu et al. 2014). In non‐pathologic conditions, as demonstrated by Taouis et al. (2002) in rats receiving an N‐3 supplementation, despite a significant decrease in P85‐α (PI‐3K substrate) mRNA expression, IRS‐1 expression remained at normal response.