The pathophysiology of ITP is very complicated, which involves pathologic autoantibodies, destruction of platelets mediated by CD8+ cytotoxic T-cells, imbalance in T-cell cytokines, T-cell subsets, and impaired megakaryocyte maturation, with each pathologic mechanism playing different parts in different patients [21]. Here, CD8A is linked to autoimmune thrombocytopenic purpura.