IL4R and neoplasm: IL-4 and the IL-4/IL-4R signaling axis are also one of the main subjects studied, considering the therapeutic inhibition of interleukins, since IL-4 protects tumor cells from CD95- and chemotherapy-induced apoptosis through the upregulation of antiapoptotic proteins, IL-4R has proven to directly promote mammary tumor metastasis and that blocking IL-4 protects against the macrophage-mediated radioresistance of inflammatory breast cancer [20-21].