ERBB2 and breast cancer: Xiao-Bo et al. reported that polymorphism in the IL-2 gene was connected to increased rates of breast cancer and could be used as a marker for the prognosis of the disease while Muraro et al. studied patients with human epidermal growth factor receptor 2 (HER-2) - overexpressing and negative - in locally advanced breast cancer and reported that IL-2 can influence the initiation and development of cancer in HER-2 patients since they proved to carry considerably lower amounts of IL-2 [14-15].