We conducted an extensive literature search of Google Scholar and PubMed (National Library of Medicine, Bethesda, MD) using a combination of terms, including “hypertriglyceridemia,” “pancreatitis,” “insulin,” and “treatment.” A total of 147 studies were initially obtained, consisting of but not limited to original articles, case series, and case reports as of July 2018. This evidence concerns the gene INS and hypertriglyceridemia.