Up to now, the main advances have been made in visceral leishmaniasis (VL) where levels of IgG1 and IgG2 antibodies, TNFα, IL10, and parasite load were proposed as biomarkers of infection (Portela et al., 2018; Martinez-Subiela et al., 2017; Corpas-lópez et al., 2016). The gene discussed is TNF; the disease is infection.