UBE2E3 and neoplasm: Expression of tumor markers WT1, transforming growth factor alpha, vascular endothelial growth factor, E3 ubiquitin-protein ligase (MIB1), and CKI 1B (p27Kip1) correlates with clinical progression of tumor (Ghanem et al., 2013), while Ki67 is a relevant marker for assessing the proliferative activity, but it may not be a good clinical prognostic marker (Jurić et al., 2010).