Besides these subgroups, other, more rare but also independent genetic subgroups of UL such as one characterized by either germline (hereditary leiomyomatosis and renal cell cancer (HLRCC), OMIM 605839) (Bayleyet al., 2008) or somatic loss-of-function mutations ofFumarate Dehydrogenase (FH) seem to exist (Kämpjärviet al., 2016). This evidence concerns the gene FH and hereditary leiomyomatosis and renal cell cancer.