In addition, p-Akt1 expression was correlated with important clinicopathologic features in the cutaneous melanomas, such as Breslow’s thickness, Clark’s level, mitotic rate, and AJCC-stage, indicating that p-Akt1 is correlated with melanoma tumorigenesis and affects the clinical outcome of these patients, emerging as a possible target for personalized therapies. This evidence concerns the gene AKT1 and cutaneous melanoma.