These findings are supported by robust experimental data: 1) an increased metastatic burden observed in lungs of ADAM28 KO mice, without regard to cancer cell type (pulmonary LLC, mammary 4T1, melanoma B16K1) or mouse strain (C57BL/6JRj and Balb/cJRj) used in experimental settings, 2) decreased CD8+ T lymphocyte counts in spleen as well as in lung tissues bearing well-developed tumors of ADAM28 KO animals, 3) the impaired CD8+ T cell recruitment already evident in the spleen of tumor-free ADAM28 deficient animals. This evidence concerns the gene CD8A and cancer.