No difference of thymocyte differentiation stages (double-negative CD4−/CD8− (DN1-4); double-positive CD4+/CD8+ (DP) (Supplementary Figure 4) or mature single positive cells (CD4+/CD8−/B220− and CD8+/CD4−/B220−) (Figure 4E, Supplementary Figure 4) could be highlighted in thymus of 8 week-old tumor-free WT and ADAM28 KO mice. The gene discussed is CD4; the disease is neoplasm.