Taken together, our data show that the observed loss in CD8+ T cell numbers is correlated with ADAM28 deficiency but is not dependent on the mouse strain (C57BL/6JRj or Balb/cJRj) or the tumor cell line used (LLC, B16K1 or 4T1) suggesting a conserved mechanism among different experimental models. The gene discussed is ADAM28; the disease is neoplasm.