ADAM10 and neoplasm: In order to verify whether other members of the ADAM family, known to have pro-tumor functions and implicated in thymocyte development and maturation, were upregulated to compensate ADAM28 deficiency, Western Blot analyses measuring ADAM10 and ADAM17 levels were performed on thymic protein extracts from WT and ADAM28 deficient mice (Supplementary Figure 1).