IDH1 and glioblastoma: Our in vitro studies confirmed that overexpression the protein of IDH1R132H in U87 MG GBM cells resulted in decreased TAGLN2 expression compared to U87 MG IDH1/2 WT parental cells and further showed that treatment of IDH1 mutant cells with 5-AZA, a DNA methyltransferase inhibitor, rescued TAGLN2 expression after demethylation.