LGR5 and neoplasm: In vivo, in a mouse model of gastric cancer that was developed by overexpressing GLI2A in Lgr5+ gastric stem cells (iLgr5;GLI2A mice) [16], GANT61 inhibition of adenocarcinoma correlated with two effects that included reduced 1) PD-L1 expression, and 2) tumor proliferation that resulted in increased CD8+ cytotoxic T lymphocytes.