While, Cis alone (Figure 8F, 8O) treatment had no effect on PD-L1 expression, GANT61 alone (Figure 8G, 8O) or in combination with Cis (Figure 8H, 8O) resulted in decreased PD-L1 expression within tumor tissue collected from the xenografts (Figure 8H, 8O). This evidence concerns the gene CD274 and neoplasm.