CUL3 and clear cell renal carcinoma: Interestingly, renal clear cell carcinoma (KIRC) and renal papillary (KIRP) had a distinct from KICH had dysregulation of the E3 ligase system from the reduced expression of CUL3. KLHL-CUL3 dysregulation may be associated with a higher level of cell cycle deregulation among the patients within that group.