We have recently described that C1-IA (complement1-inactivator), also denoted C1-inhibitor (C1-inh, C1 esterase inhibitor, serpin family G member 1), is overexpressed in glioblastomas on the gene level, protein level, and on glioblastoma cells from patients as well as and in rat glioma cell lines [3], which introduces inactivation of the complement system as an important factor to be considered in glioblastoma research. This evidence concerns the gene SERPING1 and central nervous system cancer.