PTEN and ductal breast carcinoma in situ: As displayed in Figure 3, the analysis revealed a significant upregulation of genes leading to inhibition of matrix metalloproteases in ADH (5.2-fold; p value=7.01E-06) and PTEN signaling (2.9-fold; p-value=1.43E-03), which is not observed in transition to DCIS and IDC.