In addition, regulation of epithelial to mesenchymal pathway (4.9; p-value=1.29E-05), epithelial adherens junction signaling (5.8; p-value=1.57E-06), VEGF signaling (3; p-value=1.1E-03) and actin cytoskeleton signaling (4.25; p-value=5.66E-05) were significantly upregulated in the normal-DCIS transition. Here, VEGFA is linked to ductal breast carcinoma in situ.