AVP and ductal breast carcinoma in situ: The enrichment cluster (Supplementary Figure 2A and 2B) highlighted significant gene enrichments related to collagen degradation (R-HAS-1442490), extracellular matrix organization (GO:0030198) and focal adhesion (ko04510) in ADH, whereas genes related to extracellular matrix organization (GO:0030198), epithelial cell proliferation (GO:0050673) and regulation of cell migration (GO:0030334) were enriched in DCIS.