TP53 and neoplasm: Because the two tested tumor cell lines are different in their mutational status of PTEN and p53 (i.e. mut PTEN and mut p53 in SNB19 vs. wt PTEN and wt p53 in A549), we cannot definitely conclude whether the radiosensitizing effect of PD184352 in combination with NVP-AUY922 was associated with either PTEN or p53 mutations.