In the case of small cell lung cancer (SCLC), almost 90% of tumors specifically target the RB gene with loss-of-function somatic mutations, and the remaining tumors show genetic or epigenetic alterations in either CDKN2a/p16 or other cryptic gene loci within the RB tumor suppressor pathway [6, 7]. Here, CDKN2A is linked to small cell lung carcinoma.