CDK4 and non-small cell lung carcinoma: To date, more than 200 clinical trials with CDK4/6 inhibitors have been completed or are underway in many different disease types, including breast cancer, mantle cell lymphoma, liposarcoma, NSCLC, glioblastoma multiforme, germ cell tumors, melanoma and SCLC [8, 17, 19, 20].