In another clinical trial, the CDK4/6 inhibitor, abemaciclib, was given to 49 molecularly unselected patients with advanced NSCLC, with DCR of 51% and median PFS of 2.1 months, which were comparable to our molecularly selected population (DCR 50%, median PFS 3.2 months) [47]. The gene discussed is CDK4; the disease is non-small cell lung carcinoma.