We recently reported the suppression of intracardiac expression of GM-CSF, IL-2, IFN-γ, and IL-10, as well as increased decorin and prolactin in diabetic rats and rapamycin-treated nondiabetic rats, indicating a similarity in cardiac cytokine signaling associated with both diabetes and Rap treatment [3]. This evidence concerns the gene LRPAP1 and diabetes mellitus.