TNF and psoriasis 14, pustular: The severe and intractable inflammatory conditions associated with GPP, which include leukocyte activation, mean that therapy for GPP is typically leukocytapheresis or granulocyte and monocyte apheresis, in addition to administration of methotrexate, cyclosporine, prednisolone, or biologics such as the anti-TNF-alpha antibody infliximab or the anti-IL-17 antibody secukinumab [7, 9].