Based on KEGG knowledge database, baicalin was thought to influence some important protein in these pathways directly or indirectly, especially three transcription factors—FOXO, HIF-1α, and NF-κB, which were highlighted to play important roles in the anti-ischemic stroke effect of baicalin through modulating autophagy, oxidative stress, apoptosis, angiogenesis, vascular tone stability, neuroprotective effects, inflammation, and BBB permeability. This evidence concerns the gene HIF1A and ischemic stroke.