MDR HBV is of particular interest because MDR HBV has higher chances of increased viral loads, elevated serum alanine aminotransferase (ALT) levels, and development of liver cirrhosis (LC) or hepatocellular carcinoma (HCC) owing to viral control difficulties as MDR HBV has higher risks of resistance to other NAs [6–9]. The gene discussed is GPT; the disease is cirrhosis of liver.