Consistently, upregulation of TLR4 during the development of DNP in the spinal cord has been identified, and several drugs including coenzyme Q10 and duloxetine contribute to TLR4/Myd88/NF-κB signaling pathway inhibition in the occurrence of neuropathic pain [14, 43, 44]. Here, NFKB1 is linked to neuropathic pain.