BRD4 and cancer: First studies were done in experimental proliferative pathologies, including midline carcinoma and hematological malignances, showing that JQ1 regulates cell proliferation and apoptosis, by reducing the expression of cancer-promoting genes, such as c-Myc and bcl-2, two target genes of BRD4 [79], but now, many preclinical studies have shown its beneficial effects in different pathologies.