The four lowest selection intensities among recurrently observed mutations in HPV+ tumors were one substitution within the second longest human protein MUC16 (the MUC16 gene is subject to frequent mutation in cancers and is likely spuriously associated with tumorigenesis [3]), and three synonymous substitutions within ALPK3, PCDHA6, and COL6A6. Here, COL6A6 is linked to cancer.