PMAIP1 and acute myeloid leukemia: It is well-documented that BH3 domain-only proteins, e.g., BIM and NOXA, either directly induce and activate BAX/BAK oligomers or release them from antiapoptotic BCL2, MCL1, and Bcl-xL to trigger mitochondrial outer membrane permeabilization (MOMP) and the ensuing execution phase of apoptosis in AML BPCs22–24.