Notably, as compared to vehicle control or ABBV-075 alone, cotreatment with ABBV-075 and venetoclax was also significantly more effective in reducing growth of a PDX model of AML cells (45,XX,t(3;12)(q26.1;p13),-7 with NRAS mutation) engrafted in NSG mice (Fig. 6c). This evidence concerns the gene NRAS and acute myeloid leukemia.