CD8A and infection: Investigating specifically the formation of effector or central memory CD8+ T cells, frequencies of blood and splenic effector memory (CCR7− CD45RA−) CD8+ T cells were increased in wt- as well as ΔmiR-infected animals compared to noninfected huNSG mice; however, in the absence of EBV miRNAs these frequencies were significantly lower than wt infection (Fig. S3A and C).