HLA-C and neoplasm: These data are further supported by immune gene-set analysis showing that numerous anti-tumor immune response pathways downregulated by CRT were upregulated by CRT + CTX/L-NIL, including MHC, toll-like receptor (TLR), complement system, antigen processing, DC and T cell functions (Fig. 1f; for individual sample heat map see Additional file 1: Figure S2B).