The polymorphisms of several genes, such as glucokinase regulatory protein (GCKR), tribbles homolog 1 (TRIB1), neurocan(NCAN), transmembrane 6 superfamily member 2 (TM6SF2), and Lysophospholipase-like 1(LYPLAL1), were reported to be involved in the genetic susceptibility to NAFLD [8–11]. The gene discussed is LYPLAL1; the disease is metabolic dysfunction-associated steatotic liver disease.