Therefore, in this study, we focus on the seven polymorphisms of rs1260326 (p.Leu446Pro), rs780094 in GCKR, rs2954021 near TRIB1, rs2228603 (p.Pro92Ser) in NCAN, rs58542926 (p.Glu167Lys) in TM6SF2, rs12137855 near LYPLAL1, and rs10883437 near CPN1, and assess the associations between these gene polymorphisms and NAFLD risks in the Chinese Uygur population. The gene discussed is TM6SF2; the disease is metabolic dysfunction-associated steatotic liver disease.