However, inconsistent with the previous findings that GCKR rs1260326 and rs780094 were significantly associated with insulin, triglyceride and fasting plasma glucose levels [8, 21], we did not observe significant clinical characteristics differences between the two significant polymorphisms and each genotype, suggesting their potential interaction with environment, such as BMI, obesity and age [25]. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.