In T-ALL cells, we found that MYC can be directly combined with the PD-L1 promoter to upregulate the expression of PD-L1 [104], suggesting that the EGFR pathway could up-regulate the expression of the MYC transcription factor and promote its nuclear translocation to ultimately up-regulate the expression of PD-L1. Here, MYC is linked to acute lymphoblastic leukemia.